The Great Believers is a story of the AIDS epidemic, its victims and its survivors. The story is told in alternating years, beginning with 1985 in Chicago and moving to 2015 in Paris.
The story starts with Nico’s funeral and funeral reception. Nico had died 3 weeks before the story begins. This part of the story focuses on Yale (and Charlie) and Nico’s sister, Fiona. Yale works in development at Northwestern University at the Briggs Gallery. Charlie is a gay rights activist and runs “Outloud Chicago”. Charlie and Yale have been in a long term monogamous relationship.
Nico’s parents threw him out of the house at the age of 15 when they found out he was gay. Fiona was 11 at the time and began bringing him food and money. Nico’s partner, Terrence, is just waiting for the disease to hit him.
The funeral reception takes place at photographer Richard Campo’s home. Richard is about 15 years older than the rest of the group. When someone at the party brings out slides of Nico, Yale is so upset he goes upstairs to get away from the pictures. When he comes back down everyone is gone. It is this event that causes a permanent and insoluble rift between Yale and Charlie.